There exists a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to reduce afferent agony transmission and develop analgesia. Thus, medications like clonidine that target alpha-2 receptors can affect the transmission of discomfort. Applies to clonidine: oral pill, oral tablet https://charlesa790lsg6.anchor-blog.com/profile