Environmental or self-antigens and homotypic interactions bring about BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic research have identified recurrent mutations in genes regulating tumor cell-microenvironment interactions, ... https://gloriah297zho3.corpfinwiki.com/user